Skip to main content Skip to secondary navigation

Smelling different - Mosquitoes break the one neuron / one receptor rule: Professor Leslie Vosshall, The Rockefeller University

Wu Tsai Neurosciences Institute

Event Details:

Thursday, November 5, 2020
12:00pm - 1:00pm PST

Zoom: https://stanford.zoom.us/j/94248711166?pwd=N0VwSGhKNWNueEdXZzFjdXJxbk1xUT09

Password: 391185

Leslie B. Vosshall, PhD 

Robin Chemers Neustein Professor

HHMI – Rockefeller University
Director, Kavli Neural Systems Institute

Host: Kang Shen


Abstract

Current dogma in the field of olfaction, dating from the cloning of odorant receptors by Buck and Axel in 1991, is that each olfactory sensory neuron expresses a unique odorant receptor that specifies its functional properties. All neurons expressing a given receptor project axons to a single olfactory glomerulus in the first sensory processing center in the brain, the olfactory bulb in vertebrates and antennal lobe in insects. Such an organization permits the brain to monitor activity individual glomeruli to understand what smell has been encountered. We have discovered that the Zika and dengue mosquito (Aedes aegypti) discards all of these rules. Insects have three separate super families of chemosensory receptors (ORs, IRs, and GRs). All mosquito sensory neurons profiled express multiple members of at least 2 of these receptor families. This unexpected co-expression is functional, as assessed by GCaMP imaging in the antennal lobe. A given glomerulus is activated by multiple ligands specific to different gene families. Finally, we demonstrate that this dogma-disrupting co-expression has direct functional consequences for mosquito host-seeking behavior. We speculate that this overlapping gene expression affords the female mosquito redundant and ‘unbreakable’ attraction to humans. This behavior is essential because without blood obtained from hosts, mosquitoes are unable to reproduce.

More Information: 

https://neuroscience.stanford.edu/events/series/seminar-series-2020-2021

This event is part of:

Seminar Series 2020-2021

Related Topics

Explore More Events

Nov 30
–to–
Dec 04
Research Seminars

TEACH Symposium

Monday, November 30, 2020 - Friday, December 4, 2020

Dec 03
Research Seminars

Popular Science Book Club

Thursday, December 3, 2020 | 7:00pm - 8:00pm PST