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2021 Testing Molecular Hypotheses with Materials from Human Subjects Program for Junior Investigators

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2021 Testing Molecular Hypotheses with Materials from Human Subjects Program for Junior Investigators

The mission of Stanford ChEM-H is to understand human biology at a molecular level, and to engineer molecules, materials and tools that will impact human health. A key limiting factor for testing molecular hypotheses or evaluating promising new tools in humans is the establishment of productive connections between molecular scientists/engineers with access to innovative tools and practicing clinicians with access to human subjects. To facilitate such collaborations, ChEM-H is soliciting brief proposals from small teams of clinicians and scientists/engineers who seek to undertake exploratory studies involving human subjects.

Through this solicitation, ChEM-H seeks to support research projects driven by junior investigators and aimed at testing molecular hypotheses in human subjects. Submissions must include an MD or MD/PhD investigator and a junior investigator (Assistant or Associate Professor without tenure). The junior investigator should be the principal investigator of the proposal. The physician investigator may be within any career stage. Competitive projects will have a strong mechanistic basis. Of particular interest are proposals that seek to:

  • Utilize existing samples of human cells, tissues, and/or blood to test a molecular hypothesis
  • Identify biomarkers to substantially reduce the size and/or duration of Phase 2 clinical trials for an unmet medical need

Support Provided: Applicants are expected to receive up to $25k for a 6- to 12-month workplan. Projects may be fully or partially funded. ChEM-H support does not include Clinical Research Coordinator time under this RFP.

Deadline: Proposals must be received by May 15, 2021.

Eligibility: All Stanford faculty with PI eligibility, including faculty in the Clinical Educator line are welcome to apply. The principal investigator must be a tenure line Assistant or Associate Professor who has not yet received tenure. One investigator must be an MD or MD/PhD.

Instructions: Submit one PDF file containing the following in the order indicated below. All documents should be single-spaced, Arial 11 point font with 0.5” margins.

Apply now! 

  1. Title page (1 page)
  • “Testing Molecular Hypotheses with Materials from Human Subjects Program for Junior Investigators”
  • Project Title
  • Principal investigator name, department, address, phone number, and e-mail address. The principal investigator must be the junior investigator.
  • Co-investigator(s) name department, address, phone number, and e-mail address
  1. Proposal (5 pages max total)
    • Project narrative and figures that explain background and aims of the research project. Aims must be achievable within 6-12 months. Describe the significance and innovation of the hypothesis and aims as well as pitfalls and alternative strategies (3 pages max)
    • A statement on the roles and expertise of each co-applicant and how they combine to further the project goal (1 page max)
    • References (1 page max)
  2. Budget- up to $25,000 in direct costs for study related expenses
    • Faculty and clinician time cannot be supported on this award
    • Budget should reflect that majority of the funds is allotted to the principal investigator
  3. Budget Justification
    • Describe how the proposed research justifies the requested budget.
  4. NIH Format Biosketch for each investigator

You will also need to provide a 200-word project description aimed at a general audience as part of the application forms.

Proposals should be submitted directly to the Stanford ChEM-H SlideRoom portal:  Applicants do not need to submit proposals to the Research Management Group (RMG) or Office of Sponsored Research (OSR). If awarded, the principal (junior faculty) investigator will complete a Proposal Development Routing Form (PDRF) via SeRA.

Selection Process & Timeline: A committee of faculty reviewers will identify the most meritorious proposals. Final decisions on full proposals will be made by June 1, 2021 for immediate project start.

For questions about the funding opportunity, please contact the program manager: Elizabeth Sefton, Ph.D., Scientific Program Manager, Stanford ChEM-H

For questions about ChEM-H, please contact: Carolyn Bertozzi, Ph.D., Baker Family Director, Stanford ChEM-H