Chemoproteomics Seed Grant

Applications accepted for Track 1 (budget of $50,000) or Track 2 (budget of up to $25,000). Applicants with projects focusing on characterizing protein-small molecule interactions should consider applying jointly to Macromolecular Structure. (See Chemoproteomics/Macromolecular Structure – Joint Seed Grant Proposal)

Chemoproteomics projects will include experimental design, sample preparation, LC-MS/MS acquisition, data analysis and data interpretation of complex protein and peptide samples (e.g. enriched proteins, cell lysates, biofluids, tissue biopsies, etc.). This will cover various projects, such as global proteomics (abundance profiling, activity-based protein profiling), analysis of post-translational modifications (phosphorylation, acetylation, glycoproteomics), interaction analyses (immunoprecipitation, affinity purification), structural proteomics, intact protein analysis, or absolute protein quantification, among others.

In-kind support will include one-on-one training, sample preparation, LC-MS/MS measurement time, data analysis (access to licensed software, help with coding for data analysis), and project-associated consumables.

Competitive projects will have a strong hypothesis with therapeutic relevance and experimental data to support it. The proposal must identify at least one graduate student or postdoctoral scholar who will devote at least 15% of time to the project. The student or postdoctoral scholar should expect to spend that time in the Nucleus lab space and further analyzing data remotely.

Chemoproteomics is led by Dina Schuster (dschust@stanford.edu).