Nucleus
The Nucleus at Sarafan ChEM-H is a group of breakthrough technology labs supercharging research on the path from molecules to medicines
Seed Grant: launch a new Nucleus project
Applications are now open for the 2024 Sarafan ChEM-H Seed Grant, which sill support new projects in one of the following scientific areas in the Nucleus: Medicinal Chemistry, Metabolomics, Macromolecular Structure, Cryogenic Electron Microscopy, or High-Throughput Screening.
Applications due January 17, 2025
What is the Nucleus?
The road from molecules to medicines, from discovery to translation, is complex. No single lab is equipped to address each hurdle on the path. The Nucleus at Sarafan ChEM-H is a cluster of labs that bring scientific expertise, tools, and flexibility to Stanford. Led by a unique cadre of scientific directors, the groups at the Nucleus provide technical expertise, industry perspective, cutting-edge instruments and training to Stanford labs. From metabolomics to crystallography, from medicinal chemistry to cell therapies, the Nucleus supercharges research at Stanford.
Reach out to group leader to start a collaboration today.
Meet the group leaders
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Clinical Associate Professor -
Director of Preclinical Pharmacology -
Research Engineer -
Director of Crystallography -
Director of Protein Engineering -
Alliance Director -
Director of Microbiome Therapies -
Director of High-Throughput Screening -
Head of Medicinal Chemistry -
Assistant Director, Cryo-Electron Microscopy
Areas of expertise
Cell and Gene Therapies
Designing and producing high-quality AAV vectors, and developing next-generation vectors to advance new medicines.
Clinical trials
Providing logistical, scientific and regulatory support for first-of-their kind clinical trials, including patient selection, regulatory affairs , and trial design.
Cryogenic electron microscopy
Training researchers in cutting-edge, high-resolution techniques to answer questions from human health to energy storage.
High-throughput screening
Providing expertise and resources to conduct large library screens of small molecules, siRNA, and cDNA.
Industrial Alliances
Building and sustaining industry collaborations
Medicinal chemistry
Helping biologists and clinicians incorporate drug development into their ongoing research endeavors.
Metabolomics
Leveraging mass spectrometry and allied techniques to measure and understand the biology of small molecules, including metabolites and lipids.
Microbiome Engineering
Providing researchers with well-defined, complex, and GMP-produced microbial communities.
Preclinical pharmacology
Helping Stanford scientifists identify, develop, and analyze the key studies that validate new drug prototypes.
Protein crystallography
Advising on all steps of protein production, structural analysis, and refinement and serving as a gateway for Stanford researchers to study biological molecules using SLAC X-ray facilities.
Protein engineering
Bringing therapeutic protein discovery and development to Stanford researchers to help turn more discoveries into real therapeutics.