What is the Nucleus?
The road from molecules to medicines, from discovery to translation, is complex. No single lab is equipped to address each hurdle on the path. The Nucleus at Sarafan ChEM-H is a cluster of labs that bring scientific expertise, tools, and flexibility to Stanford. Led by a unique cadre of scientific directors, the groups at the Nucleus provide technical expertise, industry perspective, cutting-edge instruments and training to Stanford labs. From metabolomics to crystallography, from medicinal chemistry to cell therapies, the Nucleus supercharges research at Stanford.
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Meet the group leaders
- Clinical Associate Professor
- Director of Preclinical Pharmacology
- Director of Metabolomics
- Director of Crystallography
- Director of Protein Engineering
- Alliance Director
- Director of Microbiome Therapies
- Director of High-Throughput Screening
- Head of Medicinal Chemistry
- Director of Cell and Gene Therapies
- Assistant Director, Cryo-Electron Microscopy
Areas of expertise
Medicinal chemistry
Helping biologists and clinicians incorporate drug development into their ongoing research endeavors.
Protein crystallography
Advising on all steps of protein production, structural analysis, and refinement and serving as a gateway for Stanford researchers to study biological molecules using SLAC X-ray facilities.
Cryogenic electron microscopy
Training researchers in cutting-edge, high-resolution techniques to answer questions from human health to energy storage.
Protein engineering
Bringing therapeutic protein discovery and development to Stanford researchers to help turn more discoveries into real therapeutics.
Preclinical pharmacology
Helping Stanford scientifists identify, develop, and analyze the key studies that validate new drug prototypes.
Metabolomics
Leveraging mass spectrometry and allied techniques to measure and understand the biology of small molecules, including metabolites and lipids.
Clinical trials
Providing logistical, scientific and regulatory support for first-of-their kind clinical trials, including patient selection, regulatory affairs , and trial design.
Microbiome Engineering
Providing researchers with well-defined, complex, and GMP-produced microbial communities.
High-throughput screening
Providing expertise and resources to conduct large library screens of small molecules, siRNA, and cDNA.
Industrial Alliances
Building and sustaining industry collaborations