Nucleus
The Nucleus at Sarafan ChEM-H is a group of breakthrough technology labs supercharging research on the path from molecules to medicines
What is the Nucleus?
The road from molecules to medicines, from discovery to translation, is complex. No single lab is equipped to address each hurdle on the path. The Nucleus at Sarafan ChEM-H is a cluster of labs that bring scientific expertise, tools, and flexibility to Stanford. Led by a unique cadre of scientific directors, the groups at the Nucleus provide technical expertise, industry perspective, cutting-edge instruments and training to Stanford labs. From metabolomics to crystallography, from medicinal chemistry to cell therapies, the Nucleus supercharges research at Stanford.
Reach out to group leader to start a collaboration today.
Meet the group leaders
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Christopher William Carreras
Director of Preclinical Pharmacology -
Yuqin Dai
Director of Metabolomics -
Daniel Fernandez
Director of Crystallography -
Adrian Hugenmatter
Director of Protein Engineering -
Paul S Humphries
Alliance Director -
Amy Jacobson
Director of Microbiome Therapies -
Bruce Koch, Ph.D.
Director of High-Throughput Screening -
Corey Liu
Associate Director, Nucleus Operations and Facilities Planning -
Dina Schuster
Assistant Director, Chemoproteomics -
Mark Smith
Head of Medicinal Chemistry -
Fabrizia Urbinati
Director of Cell and Gene Therapies -
Sheena Vasquez
Basic Life Research Scientist
Areas of expertise
Cell and Gene Therapies
Designing and producing high-quality AAV vectors, and developing next-generation vectors to advance new medicines.
Chemoproteomics
Providing researchers with access to advanced instrumentation and technical guidance for a wide range of mass spectrometry-based techniques to study proteins and their molecular interactions.
Cryogenic electron microscopy
Training researchers in cutting-edge, high-resolution techniques to answer questions from human health to energy storage.
High-throughput screening
Providing expertise and resources to conduct large library screens of small molecules, siRNA, and cDNA.
Industrial Alliances
Building and sustaining industry collaborations
Medicinal chemistry
Helping biologists and clinicians incorporate drug development into their ongoing research endeavors.
Metabolomics
Leveraging mass spectrometry and allied techniques to measure and understand the biology of small molecules, including metabolites and lipids.
Microbiome Engineering
Providing researchers with well-defined, complex, and GMP-produced microbial communities.
Protein crystallography
Advising on all steps of protein production, structural analysis, and refinement and serving as a gateway for Stanford researchers to study biological molecules using SLAC X-ray facilities.
Preclinical pharmacology
Helping Stanford scientifists identify, develop, and analyze the key studies that validate new drug prototypes.
Protein engineering
Bringing therapeutic protein discovery and development to Stanford researchers to help turn more discoveries into real therapeutics.