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Nucleus

The Nucleus at Sarafan ChEM-H is a group of breakthrough technology labs supercharging research on the path from molecules to medicines

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What is the Nucleus?

The road from molecules to medicines, from discovery to translation, is complex. No single lab is equipped to address each hurdle on the path. The Nucleus at Sarafan ChEM-H is a cluster of labs that bring scientific expertise, tools, and flexibility to Stanford. Led by a unique cadre of scientific directors, the groups at the Nucleus provide technical expertise, industry perspective, cutting-edge instruments and training to Stanford labs. From metabolomics to crystallography, from medicinal chemistry to cell therapies, the Nucleus supercharges research at Stanford.

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Meet the group leaders

Medicinal chemistry

Helping biologists and clinicians incorporate drug development into their ongoing research endeavors.

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Protein crystallography

Advising on all steps of protein production, structural analysis, and refinement and serving as a gateway for Stanford researchers to study biological molecules using SLAC X-ray facilities.

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Cryogenic electron microscopy

Training researchers in cutting-edge, high-resolution techniques to answer questions from human health to energy storage.

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Group Leader

Protein engineering

Bringing therapeutic protein discovery and development to Stanford researchers to help turn more discoveries into real therapeutics.

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Group Leader

Preclinical pharmacology

Helping Stanford scientifists identify, develop, and analyze the key studies that validate new drug prototypes.

Metabolomics

Leveraging mass spectrometry and allied techniques to measure and understand the biology of small molecules, including metabolites and lipids.

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Clinical trials

Providing logistical, scientific and regulatory support for first-of-their kind clinical trials, including patient selection, regulatory affairs , and trial design.

Group Leader

  • Jenna Bollyky

Microbiome Engineering

Providing researchers with well-defined, complex, and GMP-produced microbial communities.

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High-throughput screening

Providing expertise and resources to conduct large library screens of small molecules, siRNA, and cDNA.

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Group Leader

Industrial Alliances

Building and sustaining industry collaborations

Group Leader